| Gene Information | |
|---|---|
| Gene Name | RASEF |
| Organism | Homo sapiens (Human) |
| Gene Length | 740 |
| Protein Names | Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165105 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IZ41 |
| Gene Card | RASEF |
| Uniprot ID | Q8IZ41 |
| Pfam | PF13499; PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.798822389) |
| Ortholog in Animals | Alpaca_ RASEF ( ortholog_one2one ) Dog_ RASEF ( ortholog_one2one ) GuineaPig_ RASEF ( ortholog_one2one ) Macaque_ RASEF ( ortholog_one2one ) Mouse_ Rasef ( ortholog_one2one ) Rat_ Rasef ( ortholog_one2one ) Rabbit_ RASEF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB5A, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB20, RAB24, RAB44, RAB1A, RAB11A, RAB31, RAB7A, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB4A, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB2B, RAB2A, RAB43, RAB18, RAB37, RAB25, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB21, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB35, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27 |
| Tissue | NA |
| Tissue Specificity | Down-regulated in cutaneous melanoma cells but not in breast cancer cells. {ECO:0000269|PubMed:16174859}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001303(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2P5S (X-ray 2.15A ) 2PMY (X-ray 2.30A ) |
| DBSNP | rs4146960 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000269|PubMed:17448446}. |
| Mouse PG classification | NA |
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