| Gene Information | |
|---|---|
| Gene Name | AGTR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 363 |
| Protein Names | Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2 receptor) |
| Target Name | angiotensin ii receptor type-2 |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000180772 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P50052 |
| Gene Card | AGTR2 |
| Uniprot ID | P50052 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.455380054) |
| Ortholog in Animals | Alpaca_ AGTR2 ( ortholog_one2one ) Dog_ AGTR2 ( ortholog_one2one ) Macaque_ AGTR2 ( ortholog_one2one ) Mouse_ Agtr2 ( ortholog_one2one ) Pig_ AGTR2 ( ortholog_one2one ) Rat_ Agtr2 ( ortholog_one2one ) Rabbit_ AGTR2 ( ortholog_one2one ) |
| Ohnologs | CCR6, ACKR3, AGTR1 |
| Paralogs | AGTR1, APLNR, GPR15, GPR25, RXFP4, BDKRB2, BDKRB1 |
| Tissue | lung, uterus |
| Tissue Specificity | In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. {ECO:0000269|PubMed:12089445}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);0.200000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5UNF (X-ray 2.80A ) 5UNG (X-ray 2.80A ) 5UNH (X-ray 2.90A ) 5XJM (X-ray 3.20A ) 6JOD (X-ray 3.20A ) 7C6A (X-ray 3.40A ) 7JNI (X-ray 3.00A ) |
| DBSNP | rs121917810 rs3729977 rs5191 rs1042860 rs35474657 rs121917811 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P35374}; Multi-pass membrane protein {ECO:0000269|PubMed:28379944, ECO:0000269|PubMed:29967536, ECO:0000269|PubMed:31899086, ECO:0000269|PubMed:32669569}. |
| Mouse PG classification | NA |
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