| Gene Information | |
|---|---|
| Gene Name | AGTR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 359 |
| Protein Names | Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor) |
| Target Name | angiotensin ii receptor type-1 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000144891 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P30556 |
| Gene Card | AGTR1 |
| Uniprot ID | P30556 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.591075775) |
| Ortholog in Animals | Alpaca_ AGTR1 ( ortholog_one2one ) Dog_ AGTR1 ( ortholog_one2one ) GuineaPig_ AGTR1 ( ortholog_one2one ) Macaque_ AGTR1 ( ortholog_one2one ) Mouse_ Agtr1a ( ortholog_one2many ) Mouse_ Agtr1b ( ortholog_one2many ) Pig_ AGTR1 ( ortholog_one2one ) Rat_ Agtr1b ( ortholog_one2many ) Rat_ Agtr1a ( ortholog_one2many ) Rabbit_ AGTR1 ( ortholog_one2one ) |
| Ohnologs | GPR15, CX3CR1, CCR9, CMKLR1, AGTR2, CCR4, FPR3, CXCR4 |
| Paralogs | AGTR2, APLNR, GPR15, GPR25, RXFP4, BDKRB2, BDKRB1 |
| Tissue | NA |
| Tissue Specificity | Liver, lung, adrenal and adrenocortical adenomas. {ECO:0000269|PubMed:1378723}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4YAY (X-ray 2.90A ) 4ZUD (X-ray 2.80A ) 6DO1 (X-ray 2.90A ) 6OS0 (X-ray 2.90A ) 6OS1 (X-ray 2.79A ) 6OS2 (X-ray 2.70A ) |
| DBSNP | rs12721226 rs17852013 rs12721225 rs104893677 rs1064533 rs1801021 rs17852012 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:33713620}; Multi-pass membrane protein {ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768}. |
| Mouse PG classification | NA |
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