| Gene Information | |
|---|---|
| Gene Name | AGT |
| Organism | Homo sapiens (Human) |
| Gene Length | 485 |
| Protein Names | Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4] |
| Target Name | angiotensinogen |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000135744 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01019 |
| Gene Card | AGT |
| Uniprot ID | P01019 |
| Pfam | PF00079 |
| In ASD | no |
| Allosteric Prediction | yes (1.638459945) |
| Ortholog in Animals | Alpaca_ AGT ( ortholog_one2one ) Dog_ AGT ( ortholog_one2one ) GuineaPig_ AGT ( ortholog_one2one ) Macaque_ AGT ( ortholog_one2one ) Mouse_ Agt ( ortholog_one2one ) Pig_ AGT ( ortholog_one2one ) Rat_ Agt ( ortholog_one2one ) Rabbit_ AGT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SERPING1, SERPINB7, SERPINF1, SERPINI1, SERPIND1, SERPINA7, SERPINB8, SERPINA6, SERPINI2, HMSD, SERPINB6, SERPINC1, SERPINB1, SERPINA10, SERPINH1, SERPINB13, SERPINA3, SERPINA5, SERPINA9, SERPINA12, SERPINE1, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2 |
| Tissue | NA |
| Tissue Specificity | Expressed by the liver and secreted in plasma. {ECO:0000269|PubMed:1692023}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005276(Rat);0.133333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1N9U (NMR - ) 1N9V (NMR - ) 2JP8 (NMR - ) 2WXW (X-ray 3.30A ) 2X0B (X-ray 4.33A ) 3CK0 (X-ray 3.00A ) 3WOO (X-ray 1.80A ) 3WOR (X-ray 2.10A ) 4AA1 (X-ray 1.99A ) 4APH (X-ray 1.99A ) 4FYS (X-ray 2.01A ) 5E2Q (X-ray 2.40A ) 5M3X (X-ray 2.63A ) 5M3Y (X-ray 2.30A ) 5XJM (X-ray 3.20A ) 6I3F (X-ray 2.55A ) 6I3I (X-ray 2.97A ) 6JOD (X-ray 3.20A ) 6OS0 (X-ray 2.90A ) 7C6A (X-ray 3.40A ) |
| DBSNP | rs41271499 rs11568032 rs2229389 rs34829218 rs4762 rs765678426 rs5041 rs11568053 rs699 rs56073403 rs17856352 rs74315283 rs1805090 |
| Subcellular location [CC] | Secreted {ECO:0000305|PubMed:4300938, ECO:0000305|PubMed:7259779, ECO:0000305|PubMed:7539791}. |
| Mouse PG classification | NA |
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