| Gene Information | |
|---|---|
| Gene Name | AGR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 166 |
| Protein Names | Anterior gradient protein 3 (AG-3) (AG3) (hAG-3) (Anterior gradient 3 homolog) (Breast cancer membrane protein 11) (Protein disulfide isomerase family A, member 18) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000173467 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8TD06 |
| Gene Card | AGR3 |
| Uniprot ID | Q8TD06 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.264582916) |
| Ortholog in Animals | Alpaca_ AGR3 ( ortholog_one2one ) Macaque_ AGR3 ( ortholog_one2one ) Mouse_ Agr3 ( ortholog_one2one ) Rat_ Agr3 ( ortholog_one2one ) Rabbit_ AGR3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AGR2, TXNDC12 |
| Tissue | colon, lung, small.intestine, small.intestine.Peyers.patch, transverse.colon |
| Tissue Specificity | Expressed in the lung, in the ciliated cells of the airway epithelium (PubMed:25751668). Expression increased with differentiation of airway epithelial cells (PubMed:25751668). Not detected in the mucous cells (PubMed:25751668). Expressed in ciliated cells in the oviduct (PubMed:26170690). Also detected in stomach, colon, prostate and liver (PubMed:25751668). Expressed in breast, ovary, prostate and liver cancer (PubMed:26170690). Expression is associated with the level of differentiation of breast cancer (at protein level) (PubMed:26170690). {ECO:0000269|PubMed:25751668, ECO:0000269|PubMed:26170690}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3PH9 (X-ray 1.83A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:25751668}. Note=Found in the cytoplasm, which could include the endoplasmic reticulum. {ECO:0000305|PubMed:26170690}. |
| Mouse PG classification | NA |
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