| Gene Information | |
|---|---|
| Gene Name | NOTCH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2321 |
| Protein Names | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] |
| Target Name | notch-3 receptor |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000074181 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UM47 |
| Gene Card | NOTCH3 |
| Uniprot ID | Q9UM47 |
| Pfam | PF12796; PF13857; PF00008; PF07645; PF12661; PF06816; PF07684; PF00066 |
| In ASD | no |
| Allosteric Prediction | no (-0.322014904) |
| Ortholog in Animals | Alpaca_ NOTCH3 ( ortholog_one2one ) Dog_ NOTCH3 ( ortholog_one2one ) GuineaPig_ NOTCH3 ( ortholog_one2one ) Macaque_ NOTCH3 ( ortholog_one2one ) Mouse_ Notch3 ( ortholog_one2one ) Pig_ NOTCH3 ( ortholog_one2one ) Rat_ Notch3 ( ortholog_one2one ) Rabbit_ NOTCH3 ( ortholog_one2one ) |
| Ohnologs | NOTCH2, NOTCH1 |
| Paralogs | SNED1, NOTCH1, NOTCH2NLA, NOTCH2NLC, NOTCH2NLB, NOTCH2NLR, NOTCH2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed in fetal and adult tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4ZLP (X-ray 2.48A ) 5CZV (X-ray 3.19A ) 5CZX (X-ray 2.10A ) 6WQU (X-ray 2.41A ) 6XSW (X-ray 2.98A ) |
| DBSNP | rs193921045 rs193921045 rs1555730189 rs1555730176 rs28937321 rs1555729610 rs1568362232 rs1555729604 rs775836288 rs773539041 rs1469620436 rs2046935167 rs137852642 rs1174625611 rs1568361985 rs1555729510 rs797045014 rs28933696 rs147373451 rs1555729486 rs1599394806 rs1555729486 rs28933697 rs1568361851 rs1568361844 rs1568361818 rs1568361818 rs1555729468 rs775267348 rs1555729455 rs1555729452 rs1555729451 rs1568361608 rs947976672 rs137852641 rs1599391986 rs1323608032 rs1555729068 rs267606915 rs1568360455 rs762734007 rs28933698 rs1313319587 rs1313319587 rs11670799 rs201118034 rs1555728814 rs75068032 rs769773673 rs777751303 rs1328784046 rs1057519101 rs995523352 rs1188569102 rs1555727942 rs1599382214 rs35769976 rs1167405466 rs1285584068 rs112197217 rs10408676 rs201680145 rs1209610920 rs367543285 rs1044009 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15350543}; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. |
| Mouse PG classification | NA |
| click here to return to the previous page | |