| Gene Information | |
|---|---|
| Gene Name | ATG4B |
| Organism | Homo sapiens (Human) |
| Gene Length | 393 |
| Protein Names | Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000168397 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y4P1 |
| Gene Card | ATG4B |
| Uniprot ID | Q9Y4P1 |
| Pfam | PF20166; PF03416 |
| In ASD | no |
| Allosteric Prediction | no (-0.652912741) |
| Ortholog in Animals | Alpaca_ ATG4B ( ortholog_one2one ) Dog_ ATG4B ( ortholog_one2one ) GuineaPig_ ATG4B ( ortholog_one2one ) Macaque_ ATG4B ( ortholog_one2one ) Mouse_ Atg4b ( ortholog_one2one ) Pig_ ATG4B ( ortholog_one2one ) Rat_ Atg4b ( ortholog_one2one ) Rabbit_ ATG4B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATG4A, ATG4C, ATG4D |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CY7 (X-ray 1.90A ) 2D1I (X-ray 2.00A ) 2Z0D (X-ray 1.90A ) 2Z0E (X-ray 1.90A ) 2ZZP (X-ray 2.05A ) 5LXH (X-ray 1.58A ) 5LXI (X-ray 1.44A ) |
| DBSNP | rs7601000 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:29165041}. Cytoplasm, cytosol {ECO:0000269|PubMed:29165041}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:29165041}. Endoplasmic reticulum {ECO:0000269|PubMed:29165041}. Mitochondrion {ECO:0000269|PubMed:29165041}. Note=Mainly localizes to the cytoplasm, including cytosol (PubMed:29165041). A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041). {ECO:0000269|PubMed:29165041}. |
| Mouse PG classification | NA |
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