| Gene Information | |
|---|---|
| Gene Name | PLA2G4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 749 |
| Protein Names | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] |
| Target Name | cytosolic phospholipase a2 |
| Target Type | Clinical trial target |
| Gene Age | 886 ( ENSG00000116711 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P47712 |
| Gene Card | PLA2G4A |
| Uniprot ID | P47712 |
| Pfam | PF00168; PF01735 |
| In ASD | yes |
| Allosteric Prediction | yes (1.448110162) |
| Ortholog in Animals | Alpaca_ PLA2G4A ( ortholog_one2one ) Dog_ PLA2G4A ( ortholog_one2one ) GuineaPig_ PLA2G4A ( ortholog_one2one ) Macaque_ PLA2G4A ( ortholog_one2one ) Mouse_ Pla2g4a ( ortholog_one2one ) Pig_ PLA2G4A ( ortholog_one2one ) Rat_ Pla2g4a ( ortholog_one2one ) Rabbit_ PLA2G4A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PLA2G4B, PLA2G4D, PLA2G4F, PLA2G4E, PLA2G4C |
| Tissue | NA |
| Tissue Specificity | Expressed in various cells and tissues such as macrophages, neutrophils, fibroblasts and lung endothelium. Expressed in platelets (at protein level) (PubMed:25102815). {ECO:0000269|PubMed:25102815}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BCI (NMR - ) 1CJY (X-ray 2.50A ) 1RLW (X-ray 2.40A ) |
| DBSNP | rs28395828 rs121434634 rs12720588 rs370896190 rs121434635 rs1557895416 rs28395831 rs2307198 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11375391}. Golgi apparatus membrane {ECO:0000269|PubMed:11375391}. Nucleus envelope. Note=Translocates to intracellular membranes in a calcium-dependent way. {ECO:0000269|PubMed:11375391}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |