Gene Information
Gene NameAGER
OrganismHomo sapiens (Human)
Gene Length404
Protein NamesAdvanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Target Nameadvanced glycosylation end product receptor
Target TypeClinical trial target
Gene Age244 ( ENSG00000204305 )
3 ( ENSG00000206320 )
3 ( ENSG00000229058 )
3 ( ENSG00000230514 )
3 ( ENSG00000231268 )
3 ( ENSG00000234729 )
3 ( ENSG00000237405 )
Evolutionary StageEumetazoa
AlphaFoldDBQ15109
Gene CardAGER
Uniprot IDQ15109
PfamPF08205; PF00047; PF13895
In ASDyes
Allosteric Predictionyes (0.99995263)
Ortholog in AnimalsAlpaca_ AGER ( ortholog_one2one )
Dog_ AGER ( ortholog_one2one )
GuineaPig_ AGER ( ortholog_one2one )
Macaque_ AGER ( ortholog_one2one )
Mouse_ Ager ( ortholog_one2one )
Pig_ AGER ( ortholog_one2one )
Rat_ Ager ( ortholog_one2one )
Rabbit_ AGER ( ortholog_one2one )
OhnologsNA
ParalogsMCAM, ALCAM, BCAM
Tissuelung
Tissue SpecificityEndothelial cells.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.003212(Rat);0.036364(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2E5E  (NMR  -  )  2ENS  (NMR  -  )  2L7U  (NMR  -  )  2LE9  (NMR  -  )  2LMB  (NMR  -  )  2M1K  (NMR  -  )  2MJW  (NMR  -  )  2MOV  (NMR  -  )  3CJJ  (X-ray  1.85A  )  3O3U  (X-ray  1.50A  )  4LP4  (X-ray  2.40A  )  4LP5  (X-ray  3.80A  )  4OF5  (X-ray  2.80A  )  4OFV  (X-ray  3.10A  )  4OI7  (X-ray  3.10A  )  4OI8  (X-ray  3.10A  )  4P2Y  (X-ray  2.30A  )  4XYN  (X-ray  2.55A  )  4YBH  (X-ray  2.40A  )  5D7F  (X-ray  1.30A  )  6VXG  (NMR  -  )  6XQ1  (X-ray  1.51A  )  6XQ3  (X-ray  1.71A  )  6XQ5  (X-ray  1.80A  )  6XQ6  (X-ray  1.90A  )  6XQ7  (X-ray  1.80A  )  6XQ8  (X-ray  1.82A  )  6XQ9  (X-ray  2.30A  )  7LML  (X-ray  2.15A  )  7LMW  (X-ray  2.50A  ) 
DBSNP rs2070600 
Subcellular location [CC][Isoform 1]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 2]: Secreted.;
[Isoform 10]: Cell membrane {ECO:0000269|PubMed:24260107};
Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.
Mouse PG classificationNA
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