| Gene Information | |
|---|---|
| Gene Name | DDX17 |
| Organism | Homo sapiens (Human) |
| Gene Length | 729 |
| Protein Names | Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000100201 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92841 |
| Gene Card | DDX17 |
| Uniprot ID | Q92841 |
| Pfam | PF00270; PF00271 |
| In ASD | no |
| Allosteric Prediction | no (-0.229901943) |
| Ortholog in Animals | Alpaca_ DDX17 ( ortholog_one2one ) Dog_ DDX17 ( ortholog_one2one ) GuineaPig_ DDX17 ( ortholog_one2one ) Macaque_ DDX17 ( ortholog_one2one ) Mouse_ Ddx17 ( ortholog_one2one ) Rat_ Ddx17 ( ortholog_one2one ) Rabbit_ DDX17 ( ortholog_one2one ) |
| Ohnologs | DDX53, DDX5 |
| Paralogs | DDX28, DDX42, DDX25, DDX47, DDX49, DDX20, DDX50, DDX41, DDX24, TDRD12, DDX5, DDX52, DDX56, DDX3X, DDX3Y, DDX59, DDX39B, DDX23, EIF4A3, DDX54, DDX10, DDX19A, DDX19B, EIF4A1, DDX6, DDX39A, DDX55, DDX18, DDX21, DDX4, DDX1, DDX53, DDX31, DDX51, DDX43, EIF4A2, DDX27, DDX46 |
| Tissue | substantia.nigra, testis |
| Tissue Specificity | Widely expressed (PubMed:8871553). Low expression, if any, in normal colonic epithelial cells (at protein level). Levels tend to increase during colon cancer progression, from very low in benign hyperplastic polyps to very high in tubular and villous adenomas (PubMed:17699760). {ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:8871553}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6UV0 (X-ray 2.60A ) 6UV1 (X-ray 2.31A ) 6UV2 (X-ray 1.89A ) 6UV3 (X-ray 1.60A ) 6UV4 (X-ray 1.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12138182, ECO:0000269|PubMed:12595555, ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:17699760, ECO:0000269|PubMed:19995069, ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:24581491, ECO:0000269|PubMed:25126784}. Nucleus, nucleolus {ECO:0000269|PubMed:17226766, ECO:0000269|PubMed:22002106}. Cytoplasm, cytosol {ECO:0000269|PubMed:25126784}. Note=In the course of bunyavirus infection, relocalizes from the nucleus to the cytosol where it binds viral RNA to antagonize replication. {ECO:0000269|PubMed:25126784}. |
| Mouse PG classification | NA |
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