| Gene Information | |
|---|---|
| Gene Name | DOCK9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2069 |
| Protein Names | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000088387 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BZ29 |
| Gene Card | DOCK9 |
| Uniprot ID | Q9BZ29 |
| Pfam | PF06920; PF20422; PF20421; PF14429; PF11878; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.218969293) |
| Ortholog in Animals | Alpaca_ DOCK9 ( ortholog_one2one ) Dog_ DOCK9 ( ortholog_one2one ) GuineaPig_ DOCK9 ( ortholog_one2one ) Macaque_ DOCK9 ( ortholog_one2one ) Mouse_ Dock9 ( ortholog_one2one ) Pig_ DOCK9 ( ortholog_one2one ) Rat_ Dock9 ( ortholog_one2one ) Rabbit_ DOCK9 ( ortholog_one2one ) |
| Ohnologs | DOCK11, DOCK10 |
| Paralogs | DOCK6, DOCK8, DOCK2, DOCK1, DOCK4, DOCK10, DOCK3, DOCK11, DOCK5, DOCK7 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle. {ECO:0000269|PubMed:12172552}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WG7 (NMR - ) 2WM9 (X-ray 2.20A ) 2WMN (X-ray 2.39A ) 2WMO (X-ray 2.20A ) |
| DBSNP | rs56010605 rs16955934 |
| Subcellular location [CC] | Endomembrane system {ECO:0000305}. Note=Associated with membranes. {ECO:0000305}. |
| Mouse PG classification | NA |
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