| Gene Information | |
|---|---|
| Gene Name | AGAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 857 |
| Protein Names | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000157985 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UPQ3 |
| Gene Card | AGAP1 |
| Uniprot ID | Q9UPQ3 |
| Pfam | PF12796; PF01412; PF00071 |
| In ASD | yes |
| Allosteric Prediction | yes (0.516862033) |
| Ortholog in Animals | Alpaca_ AGAP1 ( ortholog_one2one ) Dog_ AGAP1 ( ortholog_one2one ) GuineaPig_ AGAP1 ( ortholog_one2one ) Macaque_ AGAP1 ( ortholog_one2one ) Mouse_ Agap1 ( ortholog_one2one ) Pig_ AGAP1 ( ortholog_one2one ) Rat_ Agap1 ( ortholog_one2one ) Rabbit_ AGAP1 ( ortholog_one2one ) |
| Ohnologs | AGAP3, AGAP2, AGAP5, AGAP4, AGAP6 |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, ADAP1, SMAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, APPL2, ARFGAP3, GIT2, ADAP2, SMAP2, AGAP2, ACAP1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12388557, ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:15381706, ECO:0000269|PubMed:16079295}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7EB6 (X-ray 3.01A ) |
| DBSNP | rs17855721 rs2034648 rs762355360 rs15718 rs368301945 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12388557, ECO:0000269|PubMed:12640130}. Note=Associates with the endocytic compartment. |
| Mouse PG classification | NA |
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