| Gene Information | |
|---|---|
| Gene Name | AFP |
| Organism | Homo sapiens (Human) |
| Gene Length | 609 |
| Protein Names | Alpha-fetoprotein (Alpha-1-fetoprotein) (Alpha-fetoglobulin) |
| Target Name | alpha-fetoprotein |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000081051 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P02771 |
| Gene Card | AFP |
| Uniprot ID | P02771 |
| Pfam | PF00273 |
| In ASD | no |
| Allosteric Prediction | yes (0.466275644) |
| Ortholog in Animals | Alpaca_ AFP ( ortholog_one2one ) Dog_ AFP ( ortholog_one2one ) GuineaPig_ AFP ( ortholog_one2one ) Macaque_ AFP ( ortholog_one2one ) Mouse_ Afp ( ortholog_one2one ) Pig_ AFP ( ortholog_one2one ) Rat_ Afp ( ortholog_one2one ) Rabbit_ AFP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AFM, ALB, GC |
| Tissue | kidney, liver |
| Tissue Specificity | Plasma. Synthesized by the fetal liver and yolk sac. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3MRK (X-ray 1.40A ) |
| DBSNP | rs35765619 rs7790 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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