| Gene Information | |
|---|---|
| Gene Name | AFDN |
| Organism | Homo sapiens (Human) |
| Gene Length | 1824 |
| Protein Names | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000130396 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P55196 |
| Gene Card | AFDN |
| Uniprot ID | P55196 |
| Pfam | PF01843; PF00498; PF00595; PF00788 |
| In ASD | yes |
| Allosteric Prediction | yes (0.509342739) |
| Ortholog in Animals | Alpaca_ AFDN ( ortholog_one2one ) GuineaPig_ AFDN ( ortholog_one2one ) Macaque_ AFDN ( ortholog_one2one ) Mouse_ Afdn ( ortholog_one2one ) Pig_ AFDN ( ortholog_one2one ) Rat_ Afdn ( ortholog_one2one ) Rabbit_ AFDN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1T2M (NMR - ) 1XZ9 (NMR - ) 2AIN (NMR - ) 2EXG (NMR - ) 5A6C (X-ray 2.90A ) 7QCR (X-ray 2.28A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Note=Not found at cell-matrix AJs. {ECO:0000250|UniProtKB:O35889}. |
| Mouse PG classification | NA |
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