| Gene Information | |
|---|---|
| Gene Name | AFAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 730 |
| Protein Names | Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000196526 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N556 |
| Gene Card | AFAP1 |
| Uniprot ID | Q8N556 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.306468872) |
| Ortholog in Animals | Alpaca_ AFAP1 ( ortholog_one2one ) Dog_ AFAP1 ( ortholog_one2one ) GuineaPig_ AFAP1 ( ortholog_one2one ) Macaque_ AFAP1 ( ortholog_one2one ) Mouse_ Afap1 ( ortholog_one2one ) Pig_ AFAP1 ( ortholog_one2one ) Rat_ Afap1 ( ortholog_one2one ) Rabbit_ AFAP1 ( ortholog_one2one ) |
| Ohnologs | AFAP1L1, AFAP1L2 |
| Paralogs | AFAP1L2, AFAP1L1 |
| Tissue | NA |
| Tissue Specificity | Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma. {ECO:0000269|PubMed:17520695, ECO:0000269|PubMed:17885682}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs28406288 rs41264705 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:15485829}. |
| Mouse PG classification | NA |
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