| Gene Information | |
|---|---|
| Gene Name | AFAF |
| Organism | Homo sapiens (Human) |
| Gene Length | 294 |
| Protein Names | Equatorin (Acrosome formation-associated factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NQ60 |
| Gene Card | EQTN |
| Uniprot ID | Q9NQ60 |
| Pfam | PF15339 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is highly expressed in testis. Isoform 2 is expressed at low levels in skin and blood. {ECO:0000269|PubMed:11118625}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12337286 rs12341576 rs41305329 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes. {ECO:0000250}. |
| Mouse PG classification | NA |
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