| Gene Information | |
|---|---|
| Gene Name | ADSL |
| Organism | Homo sapiens (Human) |
| Gene Length | 484 |
| Protein Names | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000239900 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P30566 |
| Gene Card | ADSL |
| Uniprot ID | P30566 |
| Pfam | PF10397; PF00206 |
| In ASD | no |
| Allosteric Prediction | yes (0.782573931) |
| Ortholog in Animals | Alpaca_ ADSL ( ortholog_one2one ) Dog_ ADSL ( ortholog_one2one ) GuineaPig_ ADSL ( ortholog_one2one ) Macaque_ ADSL ( ortholog_one2one ) Mouse_ Adsl ( ortholog_one2one ) Pig_ ADSL ( ortholog_one2one ) Rat_ Adsl ( ortholog_one2one ) Rabbit_ ADSL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ASL, FH |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.021238(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2J91 (X-ray 1.80A ) 2VD6 (X-ray 2.00A ) 4FFX (X-ray 2.70A ) 4FLC (X-ray 2.60A ) |
| DBSNP | rs143083947 rs1311171245 rs5757921 rs119450942 rs374259530 rs756210458 rs11089991 rs28941471 rs1465152683 rs119450944 rs746501563 rs373458753 rs202064195 rs370851726 rs376533026 rs755492501 rs763542069 rs119450943 rs119450941 rs554254383 rs119450940 rs777821034 rs372895468 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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