| Gene Information | |
|---|---|
| Gene Name | SWAP70 |
| Organism | Homo sapiens (Human) |
| Gene Length | 585 |
| Protein Names | Switch-associated protein 70 (SWAP-70) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000133789 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UH65 |
| Gene Card | SWAP70 |
| Uniprot ID | Q9UH65 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | yes (0.267798711) |
| Ortholog in Animals | Alpaca_ SWAP70 ( ortholog_one2one ) Dog_ SWAP70 ( ortholog_one2one ) GuineaPig_ SWAP70 ( ortholog_one2one ) Macaque_ SWAP70 ( ortholog_one2one ) Mouse_ Swap70 ( ortholog_one2one ) Pig_ SWAP70 ( ortholog_one2one ) Rat_ Swap70 ( ortholog_one2one ) Rabbit_ SWAP70 ( ortholog_one2one ) |
| Ohnologs | DEF6 |
| Paralogs | DEF6, PLEKHD1 |
| Tissue | NA |
| Tissue Specificity | Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). {ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2DN6 (NMR - ) |
| DBSNP | rs397686 rs415895 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10681448}. Cell membrane. Nucleus {ECO:0000269|PubMed:10681448}. Cell projection, lamellipodium {ECO:0000269|PubMed:12925760}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12925760}. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760). {ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}. |
| Mouse PG classification | NA |
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