| Gene Information | |
|---|---|
| Gene Name | LHCGR |
| Organism | Homo sapiens (Human) |
| Gene Length | 699 |
| Protein Names | Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R) |
| Target Name | luteinizing hormone receptor |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000138039 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P22888 |
| Gene Card | LHCGR |
| Uniprot ID | P22888 |
| Pfam | PF00001; PF13306 |
| In ASD | yes |
| Allosteric Prediction | yes (1.154215233) |
| Ortholog in Animals | Alpaca_ LHCGR ( ortholog_one2one ) Dog_ LHCGR ( ortholog_one2one ) GuineaPig_ LHCGR ( ortholog_one2one ) Macaque_ LHCGR ( ortholog_one2one ) Mouse_ Lhcgr ( ortholog_one2one ) Pig_ LHCGR ( ortholog_one2one ) Rat_ Lhcgr ( ortholog_one2one ) Rabbit_ LHCGR ( ortholog_one2one ) |
| Ohnologs | TSHR |
| Paralogs | TSHR, FSHR |
| Tissue | ovary |
| Tissue Specificity | Gonadal and thyroid cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7FIG (EM 3.90A ) 7FIH (EM 3.20A ) 7FII (EM 4.30A ) 7FIJ (EM 3.80A ) |
| DBSNP | rs121912527 rs121912539 rs12470652 rs2293275 rs121912536 rs121912529 rs121912533 rs121912528 rs121912526 rs121912535 rs121912538 rs121912531 rs121912537 rs121912540 rs121912534 rs121912519 rs121912522 rs767343825 rs121912521 rs121912518 rs121912532 rs121912532 rs121912520 rs121912525 rs121912530 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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