Gene Information
Gene NameMUSK
OrganismHomo sapiens (Human)
Gene Length869
Protein NamesMuscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)
Target Namemuscle, skeletal receptor tyrosine-protein kinase
Target TypeNA
Gene Age645 ( ENSG00000030304 )
Evolutionary StageOpisthokonta
AlphaFoldDBO15146
Gene CardMUSK
Uniprot IDO15146
PfamPF01392; PF07679; PF07714
In ASDno
Allosteric Predictionyes (0.819341555)
Ortholog in AnimalsAlpaca_ MUSK ( ortholog_one2one )
Dog_ MUSK ( ortholog_one2one )
GuineaPig_ MUSK ( ortholog_one2one )
Macaque_ MUSK ( ortholog_one2one )
Mouse_ Musk ( ortholog_one2one )
Pig_ MUSK ( ortholog_one2one )
Rat_ Musk ( ortholog_one2one )
Rabbit_ MUSK ( ortholog_one2one )
OhnologsNTRK3, NTRK2, NTRK1
ParalogsEPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs56054734  rs775587809  rs35142681  rs55786136  rs35176182  rs55826142  rs387906803  rs2274419  rs751889864  rs766640370  rs34267283  rs41279055  rs55963442  rs56126328  rs397515450  rs34614566  rs199476083  rs757577755  rs578430  rs34115159 
Subcellular location [CC]Postsynaptic cell membrane {ECO:0000269|PubMed:23326516};
Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with acetylcholine receptors (AChR) to the postsynaptic cell membrane of the neuromuscular junction. {ECO:0000269|PubMed:23326516}.
Mouse PG classificationLPG
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