| Gene Information | |
|---|---|
| Gene Name | TNFRSF9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 255 |
| Protein Names | Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137) |
| Target Name | co-stimulatory molecule 4-1bb |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000049249 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q07011 |
| Gene Card | TNFRSF9 |
| Uniprot ID | Q07011 |
| Pfam | PF00020 |
| In ASD | no |
| Allosteric Prediction | no (-0.273911354) |
| Ortholog in Animals | Alpaca_ TNFRSF9 ( ortholog_one2one ) Dog_ TNFRSF9 ( ortholog_one2one ) GuineaPig_ TNFRSF9 ( ortholog_one2one ) Macaque_ TNFRSF9 ( ortholog_one2one ) Mouse_ Tnfrsf9 ( ortholog_one2one ) Pig_ TNFRSF9 ( ortholog_one2one ) Rat_ Tnfrsf9 ( ortholog_one2one ) Rabbit_ TNFRSF9 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | Expressed on the surface of activated T-cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6A3V (X-ray 3.39A ) 6A3W (X-ray 2.00A ) 6BWV (X-ray 2.40A ) 6CPR (X-ray 2.70A ) 6CU0 (X-ray 3.20A ) 6MGP (X-ray 2.13A ) 6MHR (X-ray 2.80A ) 6MI2 (X-ray 2.72A ) 6Y8K (X-ray 2.01A ) 7D4B (X-ray 3.14A ) |
| DBSNP | rs9657963 rs9657965 rs9657979 rs776878260 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |