| Gene Information | |
|---|---|
| Gene Name | ADPRS |
| Organism | Homo sapiens (Human) |
| Gene Length | 363 |
| Protein Names | ADP-ribosylhydrolase ARH3 (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000116863 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9NX46 |
| Gene Card | ADPRS |
| Uniprot ID | Q9NX46 |
| Pfam | PF03747 |
| In ASD | no |
| Allosteric Prediction | no (-1.078871204) |
| Ortholog in Animals | Alpaca_ ADPRS ( ortholog_one2one ) GuineaPig_ ADPRS ( ortholog_one2one ) Macaque_ ADPRS ( ortholog_one2one ) Mouse_ Adprs ( ortholog_one2one ) Pig_ ADPRS ( ortholog_one2one ) Rat_ Adprs ( ortholog_one2one ) Rabbit_ ADPRS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous (PubMed:16278211). Expressed in skin fibroblasts (PubMed:30830864). {ECO:0000269|PubMed:16278211, ECO:0000269|PubMed:30830864}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2FOZ (X-ray 1.60A ) 2FP0 (X-ray 2.05A ) 2G4K (X-ray 1.82A ) 5ZQY (X-ray 1.58A ) 6D36 (X-ray 1.70A ) 6D3A (X-ray 1.60A ) 7AKR (X-ray 1.95A ) 7AKS (X-ray 1.86A ) 7ARW (X-ray 1.31A ) 7L9F (X-ray 1.75A ) 7L9H (X-ray 1.85A ) 7L9I (X-ray 1.80A ) |
| DBSNP | rs1557732234 rs1557733311 rs200626873 rs2236387 rs201735454 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17991898, ECO:0000269|PubMed:34479984}. Cytoplasm {ECO:0000269|PubMed:16278211, ECO:0000269|PubMed:34479984}. Chromosome {ECO:0000269|PubMed:30045870}. Mitochondrion matrix {ECO:0000269|PubMed:17991898, ECO:0000269|PubMed:34479984, ECO:0000305|PubMed:22433848}. Note=Recruited to DNA lesion regions following DNA damage; ADP-D-ribose-recognition is required for recruitment to DNA damage sites. {ECO:0000269|PubMed:30045870}. |
| Mouse PG classification | NA |
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