| Gene Information | |
|---|---|
| Gene Name | VAV3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 847 |
| Protein Names | Guanine nucleotide exchange factor VAV3 (VAV-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134215 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UKW4 |
| Gene Card | VAV3 |
| Uniprot ID | Q9UKW4 |
| Pfam | PF00130; PF11971; PF00169; PF00621; PF00017; PF07653 |
| In ASD | no |
| Allosteric Prediction | yes (0.36241272) |
| Ortholog in Animals | Alpaca_ VAV3 ( ortholog_one2one ) Dog_ VAV3 ( ortholog_one2one ) GuineaPig_ VAV3 ( ortholog_one2one ) Macaque_ VAV3 ( ortholog_one2one ) Mouse_ Vav3 ( ortholog_one2one ) Rat_ Vav3 ( ortholog_one2one ) Rabbit_ VAV3 ( ortholog_one2one ) |
| Ohnologs | VAV1, VAV2 |
| Paralogs | MCF2L2, VAV1, PLEKHN1, PLEKHG4, TIAM2, ARHGEF40, ARHGEF25, VAV2, SPATA13, ARHGEF9, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, MCF2L, TRIO |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:9705494}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2D86 (NMR - ) |
| DBSNP | rs34318889 rs7528153 rs12410676 rs12403266 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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