| Gene Information | |
|---|---|
| Gene Name | SLIT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1534 |
| Protein Names | Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000187122 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75093 |
| Gene Card | SLIT1 |
| Uniprot ID | O75093 |
| Pfam | PF00008; PF12661; PF02210; PF13855; PF01463; PF01462 |
| In ASD | no |
| Allosteric Prediction | no (-0.94398878) |
| Ortholog in Animals | Alpaca_ SLIT1 ( ortholog_one2one ) Dog_ SLIT1 ( ortholog_one2one ) GuineaPig_ SLIT1 ( ortholog_one2one ) Macaque_ SLIT1 ( ortholog_one2one ) Mouse_ Slit1 ( ortholog_one2one ) Pig_ SLIT1 ( ortholog_one2one ) Rat_ Slit1 ( ortholog_one2one ) Rabbit_ SLIT1 ( ortholog_one2one ) |
| Ohnologs | SLIT2, SLIT3 |
| Paralogs | TLR9, LRRC70, LRFN2, LRFN5, SLITRK3, LRFN4, GP5, SLITRK2, LINGO1, TPBGL, SLITRK6, LRFN1, LRRN1, SLITRK1, LRTM2, SLIT3, LRRN2, LRRN3, SLIT2, LRRC38, SLITRK4, LINGO2, SLITRK5, LRRC55, LRFN3 |
| Tissue | brain, cerebral.cortex, amygdala, caudate.nucleus, hippocampus, hypothalamus, nucleus.accumbens, pituitary.gland, putamen |
| Tissue Specificity | Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. {ECO:0000269|PubMed:9813312}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2817673 |
| Subcellular location [CC] | Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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