| Gene Information | |
|---|---|
| Gene Name | ADI1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 179 |
| Protein Names | Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000182551 ) 3 ( ENSG00000280830 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9BV57 |
| Gene Card | ADI1 |
| Uniprot ID | Q9BV57 |
| Pfam | PF03079 |
| In ASD | no |
| Allosteric Prediction | no (-0.315344425) |
| Ortholog in Animals | Alpaca_ ADI1 ( ortholog_one2one ) Dog_ ADI1 ( ortholog_one2one ) GuineaPig_ ADI1 ( ortholog_one2one ) Macaque_ ADI1 ( ortholog_one2one ) Mouse_ Adi1 ( ortholog_one2one ) Pig_ ADI1 ( ortholog_one2one ) Rat_ Adi1 ( ortholog_one2one ) Rabbit_ ADI1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4QGN (X-ray 3.05A ) 7JXG (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000303|PubMed:14718544}. Nucleus {ECO:0000303|PubMed:14718544}. Cell membrane {ECO:0000303|PubMed:14718544}; Peripheral membrane protein {ECO:0000303|PubMed:14718544}; Cytoplasmic side {ECO:0000303|PubMed:14718544}. Note=Localizes to the plasma membrane when complexed to MMP14. {ECO:0000303|PubMed:14718544}. |
| Mouse PG classification | NA |
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