| Gene Information | |
|---|---|
| Gene Name | MMP25 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin) |
| Target Name | matrix metalloproteinase-25 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000008516 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H239 |
| Gene Card | MMP28 |
| Uniprot ID | Q9H239 |
| Pfam | PF00045; PF00413; PF01471 |
| In ASD | no |
| Allosteric Prediction | no (-0.036527507) |
| Ortholog in Animals | Alpaca_ MMP25 ( ortholog_one2many ) Dog_ MMP25 ( ortholog_one2one ) GuineaPig_ MMP25 ( ortholog_one2one ) Macaque_ MMP25 ( ortholog_one2one ) Mouse_ Mmp25 ( ortholog_one2one ) Pig_ MMP25 ( ortholog_one2one ) Rat_ Mmp25 ( ortholog_one2one ) |
| Ohnologs | MMP2, MMP11, MMP15, MMP8, MMP7, MMP20, MMP27, MMP13, MMP3, MMP10, MMP1, MMP17 |
| Paralogs | MMP24, MMP16, MMP21, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | appendix, bone.marrow, spleen, whole.blood |
| Tissue Specificity | Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix. |
| Mouse PG classification | NA |
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