| Gene Information | |
|---|---|
| Gene Name | ADGRV1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 6306 |
| Protein Names | Adhesion G-protein coupled receptor V1 (ADGRV1) (EC 3.4.-.-) (G-protein coupled receptor 98) (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) [Cleaved into: ADGRV1 subunit alpha; ADGRV1 subunit beta] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000164199 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | NA |
| Gene Card | ADGRV1 |
| Uniprot ID | Q8WXG9 |
| Pfam | PF00002; PF03160; PF03736 |
| In ASD | no |
| Allosteric Prediction | no (-1.257993303) |
| Ortholog in Animals | Alpaca_ ADGRV1 ( ortholog_one2one ) Dog_ ADGRV1 ( ortholog_one2one ) Macaque_ ADGRV1 ( ortholog_one2one ) Mouse_ Adgrv1 ( ortholog_one2one ) Pig_ ADGRV1 ( ortholog_one2one ) Rat_ Adgrv1 ( ortholog_one2one ) Rabbit_ ADGRV1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FREM3, FREM2, FRAS1, SLC8A1, FREM1, SLC8A3, SLC8A2 |
| Tissue | adrenal.gland |
| Tissue Specificity | Expressed at low levels in adult tissues. {ECO:0000269|PubMed:10976914}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs41311333 rs41303344 rs6889939 rs2366777 rs16868935 rs35791889 rs17544552 rs4916684 rs41303352 rs4916685 rs16868972 rs16868974 rs10037067 rs2366926 rs1878878 rs16869016 rs111033530 rs13157270 rs114137750 rs16869032 rs10067636 rs2366928 rs16869088 rs16869088 rs1131691924 rs2438374 rs770471921 rs756460900 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q8VHN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VHN7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q8VHN7}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHN7}. Note=Localizes at the ankle region of the stereocilia. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex. {ECO:0000250|UniProtKB:Q8VHN7}. |
| Mouse PG classification | HPG |
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