| Gene Information | |
|---|---|
| Gene Name | ADGRL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1447 |
| Protein Names | Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000150471 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9HAR2 |
| Gene Card | ADGRL3 |
| Uniprot ID | Q9HAR2 |
| Pfam | PF00002; PF16489; PF02140; PF01825; PF02354; PF02191 |
| In ASD | no |
| Allosteric Prediction | no (-1.15485625) |
| Ortholog in Animals | Alpaca_ ADGRL3 ( ortholog_one2one ) Dog_ ADGRL3 ( ortholog_one2one ) GuineaPig_ ADGRL3 ( ortholog_one2one ) Macaque_ ADGRL3 ( ortholog_one2one ) Mouse_ Adgrl3 ( ortholog_one2one ) Pig_ ADGRL3 ( ortholog_one2one ) Rat_ Adgrl3 ( ortholog_one2one ) Rabbit_ ADGRL3 ( ortholog_one2one ) |
| Ohnologs | ADGRL1 |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5CMN (X-ray 3.60A ) 6VHH (EM 2.97A ) |
| DBSNP | rs35106420 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26235030}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q80TS3}. Cell junction {ECO:0000250|UniProtKB:Q80TS3}. |
| Mouse PG classification | NA |
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