Gene Information
Gene NameMASP1
OrganismHomo sapiens (Human)
Gene Length699
Protein NamesMannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000127241 )
Evolutionary StageEumetazoa
AlphaFoldDBP48740
Gene CardMASP1
Uniprot IDP48740
PfamPF00431; PF00084; PF00089
In ASDno
Allosteric Predictionno (-0.367233163)
Ortholog in AnimalsAlpaca_ MASP1 ( ortholog_one2one )
Dog_ MASP1 ( ortholog_one2one )
GuineaPig_ MASP1 ( ortholog_one2one )
Macaque_ MASP1 ( ortholog_one2one )
Mouse_ Masp1 ( ortholog_one2one )
Pig_ MASP1 ( ortholog_one2one )
Rat_ Masp1 ( ortholog_one2one )
Rabbit_ MASP1 ( ortholog_one2one )
OhnologsC1R, C1S, MASP2
ParalogsPRRG2, MASP2
Tissueendometrium, heart, liver, prostate, cervix, medulla.oblongata, spinal.cord, uterus, ectocervix, endocervix, sigmoid.colon, vagina
Tissue SpecificityProtein of the plasma which is primarily expressed by liver. {ECO:0000269|PubMed:11485744, ECO:0000269|PubMed:8018603, ECO:0000269|PubMed:8240317, ECO:0000269|PubMed:9367419}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3DEM  (X-ray  2.30A  )  3GOV  (X-ray  2.55A  )  4AQB  (X-ray  4.20A  )  4DJZ  (X-ray  3.20A  )  4IGD  (X-ray  2.50A  )  4IW4  (X-ray  3.20A  )  4KKD  (X-ray  2.60A  )  7PQO  (X-ray  3.39A  ) 
DBSNP rs1062049  rs13322090  rs3774266  rs759368047  rs387906752  rs779329363  rs387906753  rs387906754 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:11485744}.
Mouse PG classificationLPG
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