| Gene Information | |
|---|---|
| Gene Name | ADGRG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1017 |
| Protein Names | Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000173698 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8IZP9 |
| Gene Card | ADGRG2 |
| Uniprot ID | Q8IZP9 |
| Pfam | PF00002; PF01825 |
| In ASD | no |
| Allosteric Prediction | no (-0.261394947) |
| Ortholog in Animals | Alpaca_ ADGRG2 ( ortholog_one2one ) Dog_ ADGRG2 ( ortholog_one2one ) GuineaPig_ ADGRG2 ( ortholog_one2one ) Macaque_ ADGRG2 ( ortholog_one2one ) Mouse_ Adgrg2 ( ortholog_one2one ) Pig_ ADGRG2 ( ortholog_one2one ) Rat_ Adgrg2 ( ortholog_one2one ) Rabbit_ ADGRG2 ( ortholog_one2one ) |
| Ohnologs | ADGRG6 |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | epididymis |
| Tissue Specificity | Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung. {ECO:0000269|PubMed:12420295, ECO:0000269|PubMed:18469038, ECO:0000269|PubMed:23338946, ECO:0000269|PubMed:27476656, ECO:0000269|PubMed:9150425}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs746638813 rs140334931 rs35974297 rs3924227 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:12420295}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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