| Gene Information | |
|---|---|
| Gene Name | GPC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 580 |
| Protein Names | Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] |
| Target Name | glypican-3 |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000147257 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51654 |
| Gene Card | GPC3 |
| Uniprot ID | P51654 |
| Pfam | PF01153 |
| In ASD | no |
| Allosteric Prediction | no (-0.463330557) |
| Ortholog in Animals | Alpaca_ GPC3 ( ortholog_one2one ) Alpaca_ GPC3 ( ortholog_one2many ) Dog_ GPC3 ( ortholog_one2one ) GuineaPig_ GPC3 ( ortholog_one2one ) Macaque_ GPC3 ( ortholog_one2one ) Mouse_ Gpc3 ( ortholog_one2one ) Pig_ GPC3 ( ortholog_one2one ) Rat_ Gpc3 ( ortholog_one2one ) Rabbit_ GPC3 ( ortholog_one2one ) |
| Ohnologs | GPC1, GPC5, GPC6, GPC2 |
| Paralogs | GPC5, GPC2, GPC4, GPC6, GPC1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in lung, liver and kidney. {ECO:0000269|PubMed:8589713}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs104894854 rs11539789 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14610063}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P13265}; Extracellular side {ECO:0000250|UniProtKB:P13265}. |
| Mouse PG classification | NA |
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