| Gene Information | |
|---|---|
| Gene Name | ADGRF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 910 |
| Protein Names | Adhesion G-protein coupled receptor F1 (G protein-coupled receptor 110) (G protein-coupled receptor KPG_012) (G protein-coupled receptor PGR19) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000153292 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q5T601 |
| Gene Card | ADGRF1 |
| Uniprot ID | Q5T601 |
| Pfam | PF00002; PF01825; PF01390 |
| In ASD | no |
| Allosteric Prediction | yes (0.066906754) |
| Ortholog in Animals | Alpaca_ ADGRF1 ( ortholog_one2one ) Dog_ ADGRF1 ( ortholog_one2one ) GuineaPig_ ADGRF1 ( ortholog_one2one ) Macaque_ ADGRF1 ( ortholog_one2one ) Mouse_ Adgrf1 ( ortholog_one2one ) Pig_ ADGRF1 ( ortholog_one2one ) Rat_ Adgrf1 ( ortholog_one2one ) Rabbit_ ADGRF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | kidney |
| Tissue Specificity | Mainly expressed in the kidney. Up-regulated in lung adenocarcinomas and prostate cancers. {ECO:0000269|PubMed:20149256}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7WU3 (EM 3.10A ) 7WU4 (EM 3.40A ) 7WU5 (EM 3.00A ) |
| DBSNP | rs1226475 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20149256}; Multi-pass membrane protein {ECO:0000255}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:20149256}. |
| Mouse PG classification | NA |
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