| Gene Information | |
|---|---|
| Gene Name | ADGRE5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 835 |
| Protein Names | Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000123146 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P48960 |
| Gene Card | ADGRE5 |
| Uniprot ID | P48960 |
| Pfam | PF00002; PF07645; PF01825 |
| In ASD | no |
| Allosteric Prediction | no (-0.160365992) |
| Ortholog in Animals | Alpaca_ ADGRE5 ( ortholog_one2many ) Dog_ ADGRE5 ( ortholog_one2one ) GuineaPig_ ADGRE5 ( ortholog_one2one ) Macaque_ ADGRE5 ( ortholog_one2one ) Mouse_ Adgre5 ( ortholog_one2one ) Pig_ ADGRE5 ( ortholog_one2one ) Rat_ Adgre5 ( ortholog_one2one ) Rabbit_ ADGRE5 ( ortholog_one2one ) |
| Ohnologs | ADGRD1, ADGRL4 |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | NA |
| Tissue Specificity | Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2BOU (X-ray 1.90A ) 7DO4 (X-ray 3.20A ) |
| DBSNP | rs2230748 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q9Z0M6}; Multi-pass membrane protein {ECO:0000255}.; [Adhesion G protein-coupled receptor E5 subunit alpha]: Secreted, extracellular space {ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |