Gene Information
Gene NameNMNAT1
OrganismHomo sapiens (Human)
Gene Length279
Protein NamesNicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1)
Target Namenicotinamide mononucleotide adenylyltransferase 1
Target TypeNA
Gene Age645 ( ENSG00000173614 )
Evolutionary StageEukaryota
AlphaFoldDBQ9HAN9
Gene CardNMNAT1
Uniprot IDQ9HAN9
PfamPF01467
In ASDno
Allosteric Predictionyes (0.046201126)
Ortholog in AnimalsAlpaca_ NMNAT1 ( ortholog_one2one )
Dog_ NMNAT1 ( ortholog_one2one )
GuineaPig_ NMNAT1 ( ortholog_one2one )
Macaque_ NMNAT1 ( ortholog_one2one )
Mouse_ Nmnat1 ( ortholog_one2one )
Pig_ NMNAT1 ( ortholog_one2one )
Rat_ Nmnat1 ( ortholog_one2one )
OhnologsNMNAT3
ParalogsNMNAT3, NMNAT2
TissueNA
Tissue SpecificityWidely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain. {ECO:0000269|PubMed:11027696, ECO:0000269|PubMed:11891043}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1GZU  (X-ray  2.90A  )  1KKU  (X-ray  2.50A  )  1KQN  (X-ray  2.20A  )  1KQO  (X-ray  2.50A  )  1KR2  (X-ray  2.30A  ) 
DBSNP rs387907294  rs138613460  rs761948762  rs760965874  rs763325435  rs756903689  rs372066126  rs771336246  rs387907292  rs387907293  rs1244511644  rs757724544  rs748913297  rs142968179  rs375110174  rs368062092  rs778606847  rs1208495291  rs150726175  rs387907291 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:11248244, ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:22842230}.
Mouse PG classificationHPG
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