| Gene Information | |
|---|---|
| Gene Name | ADGRB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1522 |
| Protein Names | Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000135298 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O60242 |
| Gene Card | ADGRB3 |
| Uniprot ID | O60242 |
| Pfam | PF00002; PF19188; PF16489; PF01825; PF02793; PF00090 |
| In ASD | no |
| Allosteric Prediction | no (-0.547594378) |
| Ortholog in Animals | Alpaca_ ADGRB3 ( ortholog_one2one ) Dog_ ADGRB3 ( ortholog_one2one ) GuineaPig_ ADGRB3 ( ortholog_one2one ) Macaque_ ADGRB3 ( ortholog_one2one ) Mouse_ Adgrb3 ( ortholog_one2one ) Pig_ ADGRB3 ( ortholog_one2one ) Rat_ Adgrb3 ( ortholog_one2one ) Rabbit_ ADGRB3 ( ortholog_one2one ) |
| Ohnologs | ADGRB1, ADGRB2 |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | brain, cerebral.cortex, cerebellum |
| Tissue Specificity | Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines. {ECO:0000269|PubMed:9533023}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4DLO (X-ray 2.30A ) |
| DBSNP | rs1932618 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21262840, ECO:0000269|PubMed:22333914}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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