| Gene Information | |
|---|---|
| Gene Name | HAUS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 278 |
| Protein Names | HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) (Enhancer of invasion-cluster) (HEI-C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000152240 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96CS2 |
| Gene Card | HAUS1 |
| Uniprot ID | Q96CS2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.00030529) |
| Ortholog in Animals | Alpaca_ HAUS1 ( ortholog_one2one ) Dog_ HAUS1 ( ortholog_one2one ) GuineaPig_ HAUS1 ( ortholog_one2one ) Macaque_ HAUS1 ( ortholog_one2one ) Mouse_ Haus1 ( ortholog_one2one ) Pig_ HAUS1 ( ortholog_one2one ) Rat_ Haus1 ( ortholog_one2one ) Rabbit_ HAUS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta. {ECO:0000269|PubMed:15082789}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001615(Rat);0.191429(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217, ECO:0000269|PubMed:30723163}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000305|PubMed:19369198}. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. Localizes to mitotic spindle microtubules. {ECO:0000269|PubMed:15082789, ECO:0000269|PubMed:30723163}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |