| Gene Information | |
|---|---|
| Gene Name | ADGRB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1584 |
| Protein Names | Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000181790 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14514 |
| Gene Card | ADGRB1 |
| Uniprot ID | O14514 |
| Pfam | PF00002; PF19188; PF16489; PF01825; PF02793; PF00090 |
| In ASD | no |
| Allosteric Prediction | no (-0.361586008) |
| Ortholog in Animals | Alpaca_ ADGRB1 ( ortholog_one2one ) Dog_ ADGRB1 ( ortholog_one2one ) GuineaPig_ ADGRB1 ( ortholog_one2one ) Macaque_ ADGRB1 ( ortholog_one2one ) Mouse_ Adgrb1 ( ortholog_one2one ) Pig_ ADGRB1 ( ortholog_one2one ) Rat_ Adgrb1 ( ortholog_one2one ) |
| Ohnologs | ADGRB2, ADGRB3 |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | brain |
| Tissue Specificity | Expressed in brain (at protein level) (PubMed:12074842, PubMed:12507886). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level) (PubMed:24509909). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue (PubMed:11875720). Reduced or no expression is observed in some glioblastomas (PubMed:12507886). {ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:12074842, ECO:0000269|PubMed:12507886, ECO:0000269|PubMed:24509909}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12074842, ECO:0000269|PubMed:26838550}; Multi-pass membrane protein {ECO:0000255}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q3UHD1}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q3UHD1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:C0HL12}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UHD1}.; [Vasculostatin-120]: Secreted {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:22330140}.; [Vasculostatin-40]: Secreted {ECO:0000269|PubMed:22330140}. |
| Mouse PG classification | NA |
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