| Gene Information | |
|---|---|
| Gene Name | ADD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 706 |
| Protein Names | Gamma-adducin (Adducin-like protein 70) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000148700 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UEY8 |
| Gene Card | ADD3 |
| Uniprot ID | Q9UEY8 |
| Pfam | PF00596 |
| In ASD | no |
| Allosteric Prediction | no (-0.304067381) |
| Ortholog in Animals | Alpaca_ ADD3 ( ortholog_one2one ) Dog_ ADD3 ( ortholog_one2one ) GuineaPig_ ADD3 ( ortholog_one2one ) Macaque_ ADD3 ( ortholog_one2one ) Mouse_ Add3 ( ortholog_one2one ) Pig_ ADD3 ( ortholog_one2one ) Rat_ Add3 ( ortholog_one2one ) Rabbit_ ADD3 ( ortholog_one2one ) |
| Ohnologs | ADD2, ADD1 |
| Paralogs | ADD1, ADD2 |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: ubiquitously expressed. {ECO:0000269|PubMed:8893809}.; Cleavage fragment 1-357 is abundantly expressed in the brain of patients with Alzheimer disease (AD), but hardly detectable in age-matched control individuals (at protein level). {ECO:0000269|PubMed:33992672}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs564185858 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q62847}. Cell membrane {ECO:0000250|UniProtKB:Q62847}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000250|UniProtKB:Q9QYB5}. Note=Full-length protein and the cleavage fragment 358-706 localize mainly to the cytoplasm, while cleavage fragment 1-357 translocates from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q9QYB5}. |
| Mouse PG classification | NA |
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