| Gene Information | |
|---|---|
| Gene Name | ADD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 726 |
| Protein Names | Beta-adducin (Erythrocyte adducin subunit beta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000075340 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P35612 |
| Gene Card | ADD2 |
| Uniprot ID | P35612 |
| Pfam | PF00596 |
| In ASD | no |
| Allosteric Prediction | no (-0.500002428) |
| Ortholog in Animals | Alpaca_ ADD2 ( ortholog_one2one ) Dog_ ADD2 ( ortholog_one2one ) GuineaPig_ ADD2 ( ortholog_one2one ) Macaque_ ADD2 ( ortholog_one2one ) Mouse_ Add2 ( ortholog_one2one ) Pig_ ADD2 ( ortholog_one2one ) Rat_ Add2 ( ortholog_one2one ) Rabbit_ ADD2 ( ortholog_one2one ) |
| Ohnologs | ADD1, ADD3 |
| Paralogs | ADD1, ADD3 |
| Tissue | bone.marrow, brain, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. {ECO:0000269|PubMed:12951058}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs4986 rs4987 rs4982 rs17855969 rs4985 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Mouse PG classification | NA |
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