| Gene Information | |
|---|---|
| Gene Name | ADCYAP1R1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 468 |
| Protein Names | Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) |
| Target Name | pacap type i receptor |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000078549 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P41586 |
| Gene Card | ADCYAP1R1 |
| Uniprot ID | P41586 |
| Pfam | PF00002; PF02793 |
| In ASD | yes |
| Allosteric Prediction | yes (1.438921706) |
| Ortholog in Animals | Alpaca_ ADCYAP1R1 ( ortholog_one2many ) Dog_ ADCYAP1R1 ( ortholog_one2one ) GuineaPig_ ADCYAP1R1 ( ortholog_one2one ) Macaque_ ADCYAP1R1 ( ortholog_one2one ) Mouse_ Adcyap1r1 ( ortholog_one2one ) Pig_ ADCYAP1R1 ( ortholog_one2one ) Rat_ Adcyap1r1 ( ortholog_one2one ) Rabbit_ ADCYAP1R1 ( ortholog_one2one ) |
| Ohnologs | SCTR, PTH2R |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2JOD (NMR - ) 3N94 (X-ray 1.80A ) 6LPB (EM 3.90A ) 6M1H (EM 3.60A ) 6M1I (EM 3.50A ) 6P9Y (EM 3.01A ) 7JQD (X-ray 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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