| Gene Information | |
|---|---|
| Gene Name | ADCY9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1353 |
| Protein Names | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000162104 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O60503 |
| Gene Card | ADCY9 |
| Uniprot ID | O60503 |
| Pfam | PF00211 |
| In ASD | no |
| Allosteric Prediction | yes (1.47272034) |
| Ortholog in Animals | Alpaca_ ADCY9 ( ortholog_one2one ) Dog_ ADCY9 ( ortholog_one2one ) GuineaPig_ ADCY9 ( ortholog_one2one ) Macaque_ ADCY9 ( ortholog_one2one ) Mouse_ Adcy9 ( ortholog_one2one ) Pig_ ADCY9 ( ortholog_one2one ) Rat_ Adcy9 ( ortholog_one2one ) Rabbit_ ADCY9 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADCY8, GUCY1B1, ADCY7, NPR2, ADCY3, GUCY1A1, ADCY1, NPR1, ADCY6, GUCY2C, GUCY2D, GUCY1A2, ADCY4, ADCY5, ADCY2, GUCY2F, NPR3 |
| Tissue | NA |
| Tissue Specificity | Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:9628827}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.449139(Mouse);NULL(Rat);0.401451(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2230739 rs61731445 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:9628827}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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