| Gene Information | |
|---|---|
| Gene Name | ADCY1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1119 |
| Protein Names | Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) |
| Target Name | adenylate cyclase type 1 |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000164742 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q08828 |
| Gene Card | ADCY1 |
| Uniprot ID | Q08828 |
| Pfam | PF16214; PF00211 |
| In ASD | no |
| Allosteric Prediction | yes (1.478558009) |
| Ortholog in Animals | Alpaca_ ADCY1 ( ortholog_one2one ) Alpaca_ ADCY1 ( ortholog_one2many ) Dog_ IGFBP1 ( ortholog_one2one ) GuineaPig_ ADCY1 ( ortholog_one2one ) Macaque_ ADCY1 ( ortholog_one2one ) Mouse_ Adcy1 ( ortholog_one2one ) Pig_ ADCY1 ( ortholog_one2one ) Rat_ Adcy1 ( ortholog_one2one ) |
| Ohnologs | ADCY7, ADCY6 |
| Paralogs | ADCY8, GUCY1B1, ADCY7, NPR2, ADCY3, GUCY1A1, NPR1, ADCY9, ADCY6, GUCY2C, GUCY2D, GUCY1A2, ADCY4, ADCY5, ADCY2, GUCY2F, NPR3 |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla. {ECO:0000269|PubMed:11549699, ECO:0000269|PubMed:8314585}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12721473 rs45444695 rs2293106 |
| Subcellular location [CC] | Membrane {ECO:0000250|UniProtKB:P19754}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19754}. Cell membrane {ECO:0000269|PubMed:11549699}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O88444}. Membrane raft {ECO:0000250|UniProtKB:P19754}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. {ECO:0000250|UniProtKB:O88444}. |
| Mouse PG classification | NA |
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