| Gene Information | |
|---|---|
| Gene Name | ADAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 381 |
| Protein Names | Arf-GAP with dual PH domain-containing protein 2 (Centaurin-alpha-2) (Cnt-a2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000184060 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NPF8 |
| Gene Card | ADAP2 |
| Uniprot ID | Q9NPF8 |
| Pfam | PF01412; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.845996458) |
| Ortholog in Animals | Alpaca_ ADAP2 ( ortholog_one2one ) Dog_ ADAP2 ( ortholog_one2one ) GuineaPig_ ADAP2 ( ortholog_one2one ) Macaque_ ADAP2 ( ortholog_one2one ) Mouse_ Adap2 ( ortholog_one2one ) Pig_ ADAP2 ( ortholog_one2one ) Rat_ Adap2 ( ortholog_one2one ) Rabbit_ ADAP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, ADAP1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, APPL2, ARFGAP3, GIT2, SMAP2, AGAP2, ACAP1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow. {ECO:0000269|PubMed:14690521}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14690521}. Cell membrane {ECO:0000269|PubMed:14690521}. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus. |
| Mouse PG classification | NA |
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