| Gene Information | |
|---|---|
| Gene Name | ADAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 374 |
| Protein Names | Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000105963 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75689 |
| Gene Card | ADAP1 |
| Uniprot ID | O75689 |
| Pfam | PF01412; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.288472516) |
| Ortholog in Animals | Dog_ ADAP1 ( ortholog_one2one ) GuineaPig_ ADAP1 ( ortholog_one2one ) Macaque_ ADAP1 ( ortholog_one2one ) Mouse_ Adap1 ( ortholog_one2one ) Pig_ ADAP1 ( ortholog_one2one ) Rat_ Adap1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, APPL2, ARFGAP3, GIT2, ADAP2, SMAP2, AGAP2, ACAP1 |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. {ECO:0000269|PubMed:10448098}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.058983(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FEH (X-ray 1.90A ) 3FM8 (X-ray 2.30A ) 3LJU (X-ray 1.70A ) 3MDB (X-ray 2.95A ) |
| DBSNP | rs10256887 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase. |
| Mouse PG classification | NA |
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