| Gene Information | |
|---|---|
| Gene Name | ADAMTSL4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1074 |
| Protein Names | ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000143382 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6UY14 |
| Gene Card | ADAMTSL4 |
| Uniprot ID | Q6UY14 |
| Pfam | PF19236; PF05986; PF08686; PF00090 |
| In ASD | no |
| Allosteric Prediction | no (-0.867479892) |
| Ortholog in Animals | Alpaca_ ADAMTSL4 ( ortholog_one2one ) Dog_ ADAMTSL4 ( ortholog_one2one ) GuineaPig_ ADAMTSL4 ( ortholog_one2one ) Macaque_ ADAMTSL4 ( ortholog_one2one ) Mouse_ Adamtsl4 ( ortholog_one2one ) Pig_ ADAMTSL4 ( ortholog_one2one ) Rat_ Adamtsl4 ( ortholog_one2one ) Rabbit_ ADAMTSL4 ( ortholog_one2one ) |
| Ohnologs | THSD4 |
| Paralogs | ADAMTS5, ADAMTSL2, ADAMTS15, ADAMTS4, ADAMTS1, ADAMTS19, ADAMTS8, ADAMTSL3, ADAMTS7, THSD4, ADAMTS3, ADAMTS20, ADAMTS6, ADAMTSL5, ADAMTS9, ADAMTS12, ADAMTS14, ADAMTS13, ADAMTSL1, ADAMTS10, ADAMTS16, ADAMTS17, PAPLN, ADAMTS2, ADAMTS18 |
| Tissue | NA |
| Tissue Specificity | Expressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lung and skeletal muscle, but weaker expression in fetal brain and skin. {ECO:0000269|PubMed:19200529}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs41317515 rs56411234 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21989719}. Note=Colocalizes with FMN1 microfibrils in the eye ECM. |
| Mouse PG classification | HPG |
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