| Gene Information | |
|---|---|
| Gene Name | ADAMTS8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 889 |
| Protein Names | A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) (METH-8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000134917 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UP79 |
| Gene Card | ADAMTS8 |
| Uniprot ID | Q9UP79 |
| Pfam | PF17771; PF19236; PF05986; PF01562; PF01421; PF00090 |
| In ASD | no |
| Allosteric Prediction | no (-0.461460728) |
| Ortholog in Animals | Alpaca_ ADAMTS8 ( ortholog_one2one ) Dog_ ADAMTS8 ( ortholog_one2one ) GuineaPig_ ADAMTS8 ( ortholog_one2one ) Macaque_ ADAMTS8 ( ortholog_one2one ) Mouse_ Adamts8 ( ortholog_one2one ) Pig_ ADAMTS8 ( ortholog_one2one ) Rat_ Adamts8 ( ortholog_one2one ) Rabbit_ ADAMTS8 ( ortholog_one2one ) |
| Ohnologs | ADAMTS1, ADAMTS5, ADAMTS4 |
| Paralogs | ADAMTS5, ADAMTSL2, ADAMTS15, ADAMTS4, ADAMTS1, ADAMTS19, ADAMTSL3, ADAMTS7, THSD4, ADAMTSL4, ADAMTS3, ADAMTS20, ADAMTS6, ADAMTSL5, ADAMTS9, ADAMTS12, ADAMTS14, ADAMTS13, ADAMTSL1, ADAMTS10, ADAMTS16, ADAMTS17, PAPLN, ADAMTS2, ADAMTS18 |
| Tissue | lung |
| Tissue Specificity | Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Mouse PG classification | NA |
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