Gene Information
Gene NameADAMTS5
OrganismHomo sapiens (Human)
Gene Length930
Protein NamesA disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2)
Target Namea disintegrin and metalloproteinase with thrombospondin motifs 5
Target TypeNA
Gene Age544 ( ENSG00000154736 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9UNA0
Gene CardADAMTS5
Uniprot IDQ9UNA0
PfamPF17771; PF19236; PF05986; PF01562; PF01421; PF00090
In ASDno
Allosteric Predictionno (-0.097551427)
Ortholog in AnimalsAlpaca_ ADAMTS5 ( ortholog_one2one )
Dog_ ADAMTS5 ( ortholog_one2one )
GuineaPig_ ADAMTS5 ( ortholog_one2one )
Macaque_ ADAMTS5 ( ortholog_one2one )
Mouse_ Adamts5 ( ortholog_one2one )
Pig_ ADAMTS5 ( ortholog_one2one )
Rat_ Adamts5 ( ortholog_one2one )
Rabbit_ ADAMTS5 ( ortholog_one2one )
OhnologsADAMTS8, ADAMTS4, ADAMTS15
ParalogsADAMTSL2, ADAMTS15, ADAMTS4, ADAMTS1, ADAMTS19, ADAMTS8, ADAMTSL3, ADAMTS7, THSD4, ADAMTSL4, ADAMTS3, ADAMTS20, ADAMTS6, ADAMTSL5, ADAMTS9, ADAMTS12, ADAMTS14, ADAMTS13, ADAMTSL1, ADAMTS10, ADAMTS16, ADAMTS17, PAPLN, ADAMTS2, ADAMTS18
TissueNA
Tissue SpecificityExpressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2RJQ  (X-ray  2.60A  )  3B8Z  (X-ray  1.40A  )  3HY7  (X-ray  1.69A  )  3HY9  (X-ray  2.02A  )  3HYG  (X-ray  1.40A  )  3LJT  (X-ray  1.60A  )  6YJM  (X-ray  2.25A  ) 
DBSNP rs457947  rs2830585  rs226794 
Subcellular location [CC]Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18992360}.
Mouse PG classificationNA
click here to return to the previous page