| Gene Information | |
|---|---|
| Gene Name | ADAM9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 819 |
| Protein Names | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) |
| Target Name | cellular disintegrin-related protein |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000168615 ) 3 ( ENSG00000282230 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13443 |
| Gene Card | ADAM9 |
| Uniprot ID | Q13443 |
| Pfam | PF08516; PF00200; PF01562; PF01421 |
| In ASD | no |
| Allosteric Prediction | yes (0.186508297) |
| Ortholog in Animals | Alpaca_ ADAM9 ( ortholog_one2one ) Dog_ ADAM9 ( ortholog_one2one ) GuineaPig_ ADAM9 ( ortholog_one2one ) Macaque_ ADAM9 ( ortholog_one2one ) Mouse_ Adam9 ( ortholog_one2one ) Pig_ ADAM9 ( ortholog_one2one ) Rat_ Adam9 ( ortholog_one2one ) Rabbit_ ADAM9 ( ortholog_one2one ) |
| Ohnologs | ADAM11, ADAM12, ADAM33, ADAM8, ADAM23, ADAM19, ADAM15, ADAM29 |
| Paralogs | ADAM20, ADAM33, ADAM19, ADAM17, ADAM28, ADAM32, ADAM21, ADAM22, ADAM2, ADAM10, ADAM15, ADAM29, ADAM7, ADAM23, ADAM18, ADAMDEC1, ADAM30, ADAM12, ADAM8, ADAM11 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. {ECO:0000269|PubMed:12054541, ECO:0000269|PubMed:7584026, ECO:0000269|PubMed:8647900, ECO:0000269|PubMed:9016778}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:8647900}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:12054541}. |
| Mouse PG classification | HPG |
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