| Gene Information | |
|---|---|
| Gene Name | ADAM33 |
| Organism | Homo sapiens (Human) |
| Gene Length | 813 |
| Protein Names | Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000149451 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BZ11 |
| Gene Card | ADAM33 |
| Uniprot ID | Q9BZ11 |
| Pfam | PF08516; PF00200; PF01562; PF01421 |
| In ASD | no |
| Allosteric Prediction | no (-0.674345908) |
| Ortholog in Animals | Alpaca_ ADAM33 ( ortholog_one2one ) Dog_ ADAM33 ( ortholog_one2one ) GuineaPig_ ADAM33 ( ortholog_one2one ) Macaque_ ADAM33 ( ortholog_one2one ) Mouse_ Adam33 ( ortholog_one2one ) Pig_ ADAM33 ( ortholog_one2one ) Rat_ Adam33 ( ortholog_one2one ) Rabbit_ ADAM33 ( ortholog_one2one ) |
| Ohnologs | ADAM28, ADAM7, ADAM2, ADAM20, ADAM30, ADAM19, ADAM21, ADAM12, ADAM8, ADAM29, ADAM9, ADAM18, ADAM32 |
| Paralogs | ADAM20, ADAM19, ADAM17, ADAM9, ADAM28, ADAM32, ADAM21, ADAM22, ADAM2, ADAM10, ADAM15, ADAM29, ADAM7, ADAM23, ADAM18, ADAMDEC1, ADAM30, ADAM12, ADAM8, ADAM11 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins. {ECO:0000269|PubMed:11814695}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1R54 (X-ray 1.85A ) 1R55 (X-ray 1.58A ) |
| DBSNP | rs41467948 rs3918392 rs41534847 rs1169229302 rs41459049 rs41483049 rs41419248 rs41382144 rs615436 rs41453444 rs3918396 rs41434648 rs41462450 rs2280091 rs2280090 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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