Gene Information
Gene NameADAM28
OrganismHomo sapiens (Human)
Gene Length775
Protein NamesDisintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (MDC-L)
Target Namedisintegrin and metalloproteinase domain-containing protein 28
Target TypeNA
Gene Age680 ( ENSG00000042980 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ9UKQ2
Gene CardADAM28
Uniprot IDQ9UKQ2
PfamPF08516; PF00200; PF01562; PF01421
In ASDno
Allosteric Predictionno (-0.318518039)
Ortholog in AnimalsAlpaca_ ADAM28 ( ortholog_one2one )
Dog_ ADAM28 ( ortholog_one2one )
GuineaPig_ ADAM28 ( ortholog_one2one )
Macaque_ ADAM28 ( ortholog_one2one )
Mouse_ Adam28 ( ortholog_one2one )
Pig_ ADAM28 ( ortholog_one2one )
Rat_ Adam28 ( ortholog_one2many )
Rabbit_ ADAM28 ( ortholog_one2one )
OhnologsADAM11, ADAM12, ADAM33, ADAM8, ADAM23, ADAM19, ADAM15, ADAM29
ParalogsADAM20, ADAM33, ADAM19, ADAM17, ADAM9, ADAM32, ADAM21, ADAM22, ADAM2, ADAM10, ADAM15, ADAM29, ADAM7, ADAM23, ADAM18, ADAMDEC1, ADAM30, ADAM12, ADAM8, ADAM11
Tissuespleen, stomach
Tissue SpecificityExpressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs267601860  rs9314282  rs17736699  rs267601862  rs7001647  rs267601864  rs36041430  rs35617826  rs7829965  rs7814768 
Subcellular location [CC][Isoform 1]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 2]: Secreted.
Mouse PG classificationNA
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