| Gene Information | |
|---|---|
| Gene Name | ADAM22 |
| Organism | Homo sapiens (Human) |
| Gene Length | 906 |
| Protein Names | Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000008277 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9P0K1 |
| Gene Card | ADAM22 |
| Uniprot ID | Q9P0K1 |
| Pfam | PF08516; PF00200; PF07974; PF01562; PF01421 |
| In ASD | no |
| Allosteric Prediction | yes (0.100718803) |
| Ortholog in Animals | Alpaca_ ADAM22 ( ortholog_one2one ) Alpaca_ ADAM22 ( ortholog_one2many ) Dog_ ADAM22 ( ortholog_one2one ) GuineaPig_ ADAM22 ( ortholog_one2one ) Macaque_ ADAM22 ( ortholog_one2one ) Mouse_ Adam22 ( ortholog_one2one ) Pig_ ADAM22 ( ortholog_one2one ) Rat_ Adam22 ( ortholog_one2one ) Rabbit_ ADAM22 ( ortholog_one2one ) |
| Ohnologs | ADAM11, ADAM23, ADAM30 |
| Paralogs | ADAM20, ADAM33, ADAM19, ADAM17, ADAM9, ADAM28, ADAM32, ADAM21, ADAM2, ADAM10, ADAM15, ADAM29, ADAM7, ADAM23, ADAM18, ADAMDEC1, ADAM30, ADAM12, ADAM8, ADAM11 |
| Tissue | cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. {ECO:0000269|PubMed:16385342}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3G5C (X-ray 2.36A ) 5Y2Z (X-ray 2.67A ) 5Y31 (X-ray 7.12A ) 7CQF (X-ray 1.80A ) |
| DBSNP | rs2279542 rs4728730 rs17255978 rs747259064 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:27066583}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V6}. |
| Mouse PG classification | NA |
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